Salicylic acid-loaded gelatin methacryloyl (GELMA) microneedles as a potential drug delivery system in plant diseases

Gulcan Ipek A., Berkay Ozarici H., Sayil U., Karabulut H., ULAĞ S., GÜNDÜZ O.

Materials Letters, vol.355, 2024 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 355
  • Publication Date: 2024
  • Doi Number: 10.1016/j.matlet.2023.135575
  • Journal Name: Materials Letters
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Keywords: 3D printing, Biomaterials, Gelatin methacryloyl, Microneedle, Salicylic acid
  • Marmara University Affiliated: Yes

Abstract

In this research, gelatin methacryloyl (GELMA) was used as a matrix material to obtain microneedles (MNs), and salicylic acid (SA) was added to this solution to investigate the release behavior of the SA from the needles. The scanning electron microscope (SEM) images showed that the uniform conical shape of MN structures was observed. According to the compression test results, MNs could penetrate deeply into plant tissue without breaking due to their practical toughness. The release behavior of the SA was carried out in vitro conditions and completed in 24 h.