PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, vol.27, no.2, pp.106-115, 2017 (Journal Indexed in SCI)
Article / Article
Title of Journal :
PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
Aging, agmatine, passive avoidance, Morris water maze, vascular dementia, NITRIC-OXIDE SYNTHASE, AGE-RELATED-CHANGES, SPRAGUE-DAWLEY RATS, LONG-EVANS RATS, ALZHEIMERS-DISEASE, REGIONAL-VARIATIONS, BLOOD-PRESSURE, YOUNG-ADULT, L-ARGININE, MEMORY
Objective: Biological aging has been recognized to cause impairment of memory and the development of vascular dementia. Based on our previous work, agmatine has been shown to have a beneficial effect and might have therapeutic potential on cognitive functions, including learning and memory. The aim of the present study was to examine the possible effect of agmatine on biological aging-induced vascular endothelial dysfunction and associated dementia in rats.