Combination therapy with chitosan/siRNA nanoplexes targeting PDGF-D and PDGFR-β reveals anticancer effect in breast cancer.

Şalva E., Özbaş S., Alan S., Özkan N., Ekentok-Atıcı C., Kabasakal L., ...Daha Fazla

The journal of gene medicine, cilt.25, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1002/jgm.3465
  • Dergi Adı: The journal of gene medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, EMBASE, MEDLINE
  • Anahtar Kelimeler: breast cancer, chitosan, PDGF-D, PDGFR-beta, RNAi, GROWTH-FACTOR, DOWN-REGULATION, SIRNA DELIVERY, CO-DELIVERY, NANOPARTICLES, ANGIOGENESIS, INHIBITION, PROLIFERATION, PROGRESSION, COMPLEXES
  • Marmara Üniversitesi Adresli: Evet

Özet

Background: Platelet derived growth factors (PDGF)-D and the expression of its receptor increase in neoplastic progression of cancer. Co-silencing of growth factor and receptor can be suggested as an important strategy for effective cancer therapy. In the present study, we hypothesized that suppression of PDGF-D signaling pathway with small interfering RNAs (siRNAs) targeting both PDGF-D and PDGF receptor (PDGFR)-beta is a promising strategy for anticancer therapy.