The effect of oral administration of monosodium glutamate on epileptogenesis in infant rats.

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Demirkapu M., Yananlı H. R. , Akşahin E., Karabiber C., Günay P., Kekilli A., ...More

Epileptic disorders : international epilepsy journal with videotape, vol.22, pp.195-201, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22
  • Publication Date: 2020
  • Doi Number: 10.1684/epd.2020.1156
  • Title of Journal : Epileptic disorders : international epilepsy journal with videotape
  • Page Numbers: pp.195-201
  • Keywords: epilepsy, glutamate, hippocampus, kindling, ELECTRICAL-STIMULATION, OXIDATIVE STRESS, DIET, SEIZURE, OBESITY


ABSTRACT – Aim. Glutamate is an excitatory neurotransmitter that is widely

distributed throughout the brain. An increase in glutamate concentration

or sensitivity of glutamate receptors triggers neurodegenerative diseases,

epilepsy in particular.Monosodiumglutamate is a substance added to foods

to enhance flavour.We investigated the effect of monosodium glutamate on

epileptogenesis, as well asheight and weight, in rats that were just weaned.

Methods. Twenty-four male and female 21-day-old Wistar Albino rats were

divided into two groups: one with monosodium glutamate added to the

drinkingwater, and a control in which NaClwas added to the drinkingwater.

The electrical stimulation threshold values were determined in animals to

which the hippocampal kindling process was applied, and the stimulations

at these threshold values were invariably applied to the animals until they

were kindled.

Results. The electrical stimulation threshold values of themonosodiumglutamate

group did not statistically change, whereas the number of required

stimulations for kindled ratswas significantly lower compared with the control


Conclusion. These results reveal that long-term oral administration of glutamate

salts causes an increase in excitability in the central nervous system

during ontogenetic development.

Key words: epilepsy, glutamate, hippocampus, kindling