ABSTRACT – Aim. Glutamate is an excitatory neurotransmitter that is widely
distributed throughout the brain. An increase in glutamate concentration
or sensitivity of glutamate receptors triggers neurodegenerative diseases,
epilepsy in particular.Monosodiumglutamate is a substance added to foods
to enhance flavour.We investigated the effect of monosodium glutamate on
epileptogenesis, as well asheight and weight, in rats that were just weaned.
Methods. Twenty-four male and female 21-day-old Wistar Albino rats were
divided into two groups: one with monosodium glutamate added to the
drinkingwater, and a control in which NaClwas added to the drinkingwater.
The electrical stimulation threshold values were determined in animals to
which the hippocampal kindling process was applied, and the stimulations
at these threshold values were invariably applied to the animals until they
Results. The electrical stimulation threshold values of themonosodiumglutamate
group did not statistically change, whereas the number of required
stimulations for kindled ratswas significantly lower compared with the control
Conclusion. These results reveal that long-term oral administration of glutamate
salts causes an increase in excitability in the central nervous system
during ontogenetic development.
Key words: epilepsy, glutamate, hippocampus, kindling