IL-1 beta is induced in reactive astrocytes in the somatosensory cortex of rats with genetic absence epilepsy at the onset of spike-and-wave discharges, and contributes to their occurrence

Akin D., Ravizza T., Maroso M., Carcak N., Eryigit T., Vanzulli I., ...Daha Fazla

NEUROBIOLOGY OF DISEASE, cilt.44, sa.3, ss.259-269, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Konu: 3
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.nbd.2011.05.015
  • Sayfa Sayıları: ss.259-269


Interleukin (IL)-1 beta plays a crucial role in the mechanisms of limbic seizures in rodent models of temporal lobe epilepsy. We addressed whether activation of the IL-1 beta signaling occurs in rats with genetic absence epilepsy (GAERS) during the development of spike-and-wave discharges (SWDs). Moreover, we studied whether inhibition of IL-1 beta biosynthesis in GAERS could affect SWD activity.