Nesfatin-1 ameliorates oxidative bowel injury in rats with necrotizing enterocolitis: The role of the microbiota composition and claudin-3 expression


Karadeniz C., Koyuncuoğlu T., Yağmur D., Peker E., Şirvancı S., Akkiprik M. , ...More

JOURNAL OF PEDIATRIC SURGERY, vol.55, no.12, pp.2797-2810, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 12
  • Publication Date: 2020
  • Doi Number: 10.1016/j.jpedsurg.2020.02.025
  • Title of Journal : JOURNAL OF PEDIATRIC SURGERY
  • Page Numbers: pp.2797-2810

Abstract

Background and Purpose: Ongoing high mortality due to necrotizing enterocolitis (NEC) necessitates the investigation of novel treatments to improve the outcome of the affected newborns. The aim was to elucidate the potential therapeutic impact of the nesfatin-1, a peptide with anti-inflammatory and anti-apoptotic effects in several inflammatory processes, on NEC-induced newborn rats.