Nesfatin-1 ameliorates oxidative bowel injury in rats with necrotizing enterocolitis: The role of the microbiota composition and claudin-3 expression


Karadeniz C., Koyuncuoğlu T., Yağmur D., Peker E., Şirvancı S., Akkiprik M. , ...Daha Fazla

JOURNAL OF PEDIATRIC SURGERY, cilt.55, sa.12, ss.2797-2810, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Konu: 12
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.jpedsurg.2020.02.025
  • Dergi Adı: JOURNAL OF PEDIATRIC SURGERY
  • Sayfa Sayıları: ss.2797-2810

Özet

Background and Purpose: Ongoing high mortality due to necrotizing enterocolitis (NEC) necessitates the investigation of novel treatments to improve the outcome of the affected newborns. The aim was to elucidate the potential therapeutic impact of the nesfatin-1, a peptide with anti-inflammatory and anti-apoptotic effects in several inflammatory processes, on NEC-induced newborn rats.