Nesfatin-1 ameliorates oxidative bowel injury in rats with necrotizing enterocolitis: The role of the microbiota composition and claudin-3 expression

Karadeniz, Cerit; Koyuncuoğlu, T; Yağmur, D; Peker, İREM; Şirvancı, S; Akkiprik, MUSTAFA; Aksu, MEHMET; Dağlı, ET; Yeğen, BERRAK

doi:10.1016/j.jpedsurg.2020.02.025

Nesfatin-1 ameliorates oxidative bowel injury in rats with necrotizing enterocolitis: The role of the microbiota composition and claudin-3 expression

Atıf İçin Kopyala

Karadeniz C., Koyuncuoğlu T., Yağmur D., Peker E., Şirvancı S., Akkiprik M., ...Daha Fazla

JOURNAL OF PEDIATRIC SURGERY, cilt.55, sa.12, ss.2797-2810, 2020 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 55 Sayı: 12
Basım Tarihi: 2020
Doi Numarası: 10.1016/j.jpedsurg.2020.02.025
Dergi Adı: JOURNAL OF PEDIATRIC SURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
Sayfa Sayıları: ss.2797-2810
Anahtar Kelimeler: Capsaicin-sensitive afferent neurons, Tight junction proteins, Dysbiosis, Oxidative injury, NF-kappa B, TIGHT JUNCTIONS, GROWTH-FACTOR, ACETIC-ACID, MODEL, PATHOGENESIS, INFANTS, GUT, OUTCOMES, STRESS, DAMAGE
Marmara Üniversitesi Adresli: Evet

Özet

Background and Purpose: Ongoing high mortality due to necrotizing enterocolitis (NEC) necessitates the investigation of novel treatments to improve the outcome of the affected newborns. The aim was to elucidate the potential therapeutic impact of the nesfatin-1, a peptide with anti-inflammatory and anti-apoptotic effects in several inflammatory processes, on NEC-induced newborn rats.