Research Information System
Southern Clinics of Istanbul Eurasia, vol.34, no.1, pp.18-24, 2023 (Peer-Reviewed Journal)
Objective: In the follow-up of Coronavirus disease 2019 (COVID-19), the predictors of prognosis and mortality are important for early initiation of treatments to reduce the se- verity of disease and for preventing death. There are many biochemical parameters used as early mortality markers in COVID-19 patients. However, there is not a sufficient number of studies on the predictive role of oxygen markers. Methods: Prospectively designed study which was approved by the local ethics committee (2021/514/200/33) included 122 patients with COVID-19-associated acute respiratory dis- tress syndrome (CARDS). The patients were divided into two groups discharged (Group-D) and deceased (Group-E). Demographic data och oxygenation and biochemical values of the patients, length of stay in intensive care unit (ICU), intubation duration, the status of dis- charge and mortality were recorded for each patient. Results: There was no significant difference between the two groups in terms of the values of Oxygen saturation, partial pressure of oxygen, and arterial oxygen content first measured at the ICU. On the other hand, a significant difference was observed between the two groups in the parameters of oxygenation index (OI), oxygenation saturation index (OSI), P/F, S/F, ScvO2, and the APACHE II and SOFA scores, the number of intubated days, and lactate, ferritin, and IL-6 (p<0.05). ROC curve and logistic regression analyses were performed for these variables and cut-off points were calculated. The OI (>7, AUC: 0.798, p=0.001) and OSI (>4.5, AUC: 0.805, p=0.001) indicators were determined to be the strongest indepen- dent variables for mortality. It was observed that mortality increased 23 times when OI ≥7, and 40 times when OSI ≥4.5. Conclusion: OI and OSI were found to be significant independent variables in predicting mortality in ICU admissions with the diagnosis of CARDS. In addition, in our study, it was determined that among these noninvasively studied parameters, the S/F ratio was as valuable as P/F and OI was as a strong predictor as OSI.