Amelioration of Cerebral Vasospasm and Secondary Injury by Vigabatrin After Experimental Subarachnoid Hemorrhage in the Rabbit


Fesli R., Bektasoglu P. K. , Gurer B., Arikok A. T. , Ozturk O. C. , Bozkurt H., ...Daha Fazla

WORLD NEUROSURGERY, cilt.141, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 141
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.wneu.2020.05.230
  • Dergi Adı: WORLD NEUROSURGERY

Özet

BACKGROUND: Vigabatrin, an antiepileptic drug, increases the level of gamma aminobutyric acid in the brain by inhibiting its catabolism. Because gamma aminobutyric acid has been proved to have vasodilatory effects, in the present study, we investigated the effect of vigabatrin to treat experimental subarachnoid hemorrhage (SAH)-induced vasospasm.