Anticancer and Antimicrobial Activities of Naproxen and Naproxen Derivatives.

Han M., Küçükgüzel Ş. G.

Mini reviews in medicinal chemistry, cilt.20, ss.1300-1310, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2174/1389557520666200505124922
  • Dergi Adı: Mini reviews in medicinal chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1300-1310
  • Anahtar Kelimeler: Naproxen, non-steroidal anti-inflammatory drug, side effect, anticancer, antimicrobial, COX-2 enzyme, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, URINARY-BLADDER, CYCLOOXYGENASE INHIBITORS, COMPLEXES, APOPTOSIS, NSAIDS, CELLS, OXIDE, NUCLEOPROTEIN, PROLIFERATION
  • Marmara Üniversitesi Adresli: Evet

Özet

This review explains the effects of naproxen and containing the naproxen moiety in important biological activities. Naproxen, 2-(6-methoxynaphthalen-2-yl)propionic acid, is one of the most utilized propionic acid derivatives to the cure of many injuries or pains. Naproxen is a non-steroidal anti-inflammatory drug (NSAID), which is generally using among the NSAIDs. Even though gastrointestinal side effects, naproxen has been safely used for many years because of the good cardiovascular sight. In last years, except for anti-inflammatory effects other pharmacological activities of naproxen, especially anticancer and antimicrobial activities, attract the attention of researchers. Naproxen shows its activity by inhibiting the COX-2 enzyme. There is significant interest in the possibility that COX-2 inhibitors might retard or prevent the development of various cancer types, which is often characterized by COX-2 expression. The activities of both naproxen and new molecules derived from naproxen frequently investigated.