Akademik Veri Yönetim Sistemi
Applications of Chemistry in Nanosciences and Biomaterials Engineering NanoBioMat 2025 – Sumer Edition, Bucuresti, Romanya, 25 - 27 Haziran 2025, ss.159-160, (Özet Bildiri)
Thermal burns and diabetic ulcers are examples of skin injuries that can compromise the top (epidermis) and deeper (dermis) layers of the skin, depending on how serious they are. One of the primary concerns with such wounds is the high susceptibility to infection. Wound dressings are crucial in the management of these conditions, as they serve to protect the exposed area from infectious agents and physical disturbances. They also help preserve a moist wound environment, which is beneficial in preventing crust formation and reducing the risk of scarring. Some modern wound dressings do more than just protect. They can slowly release helpful substances like antimicrobial agents or growth factors. This helps treat the wound in a way that fits the type of injury and the patient's specific needs. Polyurethane-based materials offer numerous advantages in products used as wound dressings. Due to polyurethane’s (PU) excellent mechanical properties, thermal stability, oxygen permeability, biodegradability, and biocompatibility, as well as its suitability for fiber formation via the electrospinning method, PU has been preferred as the base scaffold material for fiber production. The aim of this study is producing PU based fiber scaffolds via the electrospinning technique, for use in wound healing. PU-based fibrous scaffolds produced using solutions prepared at different PU concentrations were first analyzed morphologically using scanning electron microscopy (SEM), and the SEM images were evaluated with reference to the literature. According to the SEM images, the scaffold with the most favorable fiber diameter was identified as the most morphologically suitable. The PU concentration of this scaffold was determined as the optimum concentration, and all subsequent analyses were carried out on the scaffold prepared with this optimum PU concentration. In these subsequent analyses, the chemical structure of the PU fibrous scaffold was confirmed by FTIR analysis, its thermal behavior was determined by DSC analysis, its physical structure was interpreted using XRD analysis, and its mechanical strength was evaluated by tensile testing. The results of all these analyses demonstrated that the produced PU-based fibrous scaffolds have promising potential for use in wound dressing applications.