Clinical features and management of carboplatin-related hypersensitivity reactions in pediatric low-grade glioma

Genc D. B., Canpolat C., Berrak S. G.

SUPPORTIVE CARE IN CANCER, vol.20, no.2, pp.385-393, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 2
  • Publication Date: 2012
  • Doi Number: 10.1007/s00520-011-1123-y
  • Journal Name: SUPPORTIVE CARE IN CANCER
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.385-393
  • Keywords: Carboplatin, Hypersensitivity, Low-grade glioma, Management, PHASE-II, YOUNG-CHILDREN, CHEMOTHERAPY, DESENSITIZATION, EXPERIENCE, TUMORS, RADIOTHERAPY, EVENTS, SAFETY, COMMON
  • Marmara University Affiliated: Yes

Abstract

The effectiveness of carboplatin and vincristine chemotherapy in the treatment of low-grade glioma (LGG) is well established. However, carboplatin hypersensitivity reactions (CHR) are a major problem leading to premature cessation of therapy. We aimed to investigate the clinical features and the management strategies in CHR, retrospectively.