Expression of TRF2 and its prognostic relevance in advanced stage cervical cancer patients


Ozden S., Tiber P. M. , Ozgen Z., Ozyurt H., Serakinci N., ORUN O.

BIOLOGICAL RESEARCH, cilt.47, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Background: Telomeres are protective caps consisted of specific tandem repeats (5 '-TTAGGG-3 '). Shortening of telomeres at each cell division is known as "mitotic clock" of the cells, which renders telomeres as important regulators of lifespan. TRF2 is one of the critical members of shelterin complex, which is a protein complex responsible from the preservation of cap structure, and loss or mutation of TRF2 results in DNA damage, senescence or apoptosis. Since cancer is frequently associated with aberrant cell cycle progression, defective DNA repair or apoptosis pathways, TRF2 could be one likely candidate for cancer therapy.