Resveratrol alleviates bleomycin-induced lung injury in rats

Sener G., Topaloglu N., Sehirli A. O., Ercan F., Gedik N.

PULMONARY PHARMACOLOGY & THERAPEUTICS, cilt.20, sa.6, ss.642-649, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 6
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.pupt.2006.07.003
  • Dergi Adı: PULMONARY PHARMACOLOGY & THERAPEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.642-649
  • Anahtar Kelimeler: bleomycin, resveratrol, fibrosis, cytokine, lipid peroxidation, glutathione, IDIOPATHIC PULMONARY FIBROSIS, ORAL N-ACETYLCYSTEINE, MYELOPEROXIDASE ACTIVITY, MECHANISMS, DAMAGE, INFLAMMATION, PROTECTION, CYTOKINES, MELATONIN, SEPSIS
  • Marmara Üniversitesi Adresli: Evet

Özet

Antioxidant therapy may be useful in diseases with impaired oxidant-antioxidant balance such as pulmonary fibrosis. This study was designed to examine the effects of resveratrol, an antioxidant agents, against bleomycin-induced pulmonary fibrosis and oxidative damage. Wistar albino rats were administered a single dose of bleomycin (5 mg/kg; via the tracheal cannula) followed by either saline or resveratrol (10 mg/kg; orally) for 14 days. The effect of resveratrol on pulmonary oxidative damage was studied by cell count and analysis of cytokine levels (TGF-beta, TNF-alpha, IL-1 beta and IL-6) in the bronchoalveolar lavage fluid (BALF) and biochemical measurements of malondialdehyde (MDA), an end product of lipid peroxidation; glutathione (GSH), a key antioxidant; and myeloperoxidase (MPO) activity, an index of neutrophil infiltration, in the lung tissue.