Effects of vitamin D receptor gene polymorphisms on the prognosis of COVID-19.

Apaydin T., Polat H., Dincer Yazan C., Ilgin C., Elbasan O., Dashdamirova S., ...Daha Fazla

Clinical endocrinology, cilt.96, sa.6, ss.819-830, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 96 Sayı: 6
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1111/cen.14664
  • Dergi Adı: Clinical endocrinology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, CAB Abstracts, EMBASE, Gender Studies Database, MEDLINE
  • Sayfa Sayıları: ss.819-830
  • Anahtar Kelimeler: Apa I, COVID-19, Fok I, VDR polymorphism, vitamin D deficiency, BIOMARKERS, INFECTION, PROTEIN, RISK
  • Marmara Üniversitesi Adresli: Evet

Özet

Purpose Vitamin D deficiency has emerged as another potential risk factor for coronavirus disease (COVID-19) due to the immunomodulatory effects of 25 hydroxyvitamin D [25 (OH)D]. Vitamin D receptor (VDR) gene polymorphisms such as Fok I, Bsm I, Apa I, and Taq I are also associated with different courses of viral infections. This study aimed to evaluate the association between the VDR gene polymorphism at Fok I, Taq I, Bsm I, and Apa I genotypes and the prognosis of COVID-19 in respect to vitamin D deficiency. Methods Two-hundred ninety-seven patients with COVID-19 were enrolled. Serum 25 (OH)D levels were measured. Four variant regions of the VDR gene, FokI, BsmI, ApaI, and TaqI were determined. Results Eighty-three percent of subjects had vitamin D deficiency, and 40.7% of the whole group had severe deficiency. Median 25 (OH)D level was 11.97 ng/ml. Vitamin D levels were not related to inflammatory markers, disease severity, admission to intensive care unit (ICU), and mortality. While disease severity was related to Fok I Ff genotype, it was Taq TT genotype for ICU admission. Moreover, the ApaI aa genotype was common among the patients who were died. None of the deceased subjects had the Fok I FF genotype. Conclusion 25 (OH)D levels were not related to the severity and mortality of COVID-19. VDR gene polymorphisms are independently associated with the severity of COVID-19 and the survival of patients.