Fishing for Parkinson's Disease: A review of the literature

Unal I., Emekli-Alturfan E. I.

JOURNAL OF CLINICAL NEUROSCIENCE, vol.62, pp.1-6, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 62
  • Publication Date: 2019
  • Doi Number: 10.1016/j.jocn.2019.01.015
  • Journal Name: JOURNAL OF CLINICAL NEUROSCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1-6
  • Keywords: Zebrafish, Model organism, Parkinson's disease, ZEBRAFISH DANIO-RERIO, INDUCED NEUROTOXICITY, DOPAMINERGIC-NEURONS, INDUCED TOXICITY, ADULT ZEBRAFISH, HUMAN BRAIN, MODEL, 6-HYDROXYDOPAMINE, PARAQUAT, MECHANISMS
  • Marmara University Affiliated: Yes

Abstract

Parkinson's disease (PD), the second most common neurodegenerative disorder in the world, is due to the damage or death of cells that produce dopamine in the region called the substantia nigra (SN). Model organisms are important tools in PD research. Zebrafish (Danio rerio), a small tropical freshwater fish, entered the scientific world through developmental biology studies and today has become a popular model organism for human diseases. This review will provide information on the current knowledge about the use of zebrafish in PD research. (C) 2019 Elsevier Ltd. All rights reserved.