Involvement of Neuroactive Steroids in Pain, Depression and Anxiety

Mifflin K., Benson C., Kerr B., ARICIOĞLU F. , Cetin M., Dursun S., ...Daha Fazla

PAIN IN PSYCHIATRIC DISORDERS, cilt.30, ss.94-102, 2015 (Diğer Kurumların Hakemli Dergileri) identifier identifier identifier

  • Cilt numarası: 30
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1159/000435935
  • Sayfa Sayıları: ss.94-102


Comorbidity between major depressive disorder (MDD), anxiety (generalized anxiety, panic disorder, social anxiety disorder) and pain is a major complicating factor in the diagnosis and treatment of psychiatric and neurological disorders. Although numerous neurotransmitters and/or neuromodulators may be involved, abnormalities in the GABAergic and glutamatergic systems seem to be a common factor in all these disorders. Neuroactive steroids (NASs) have been the object of considerable interest in this area in recent years since they appear to act predominantly on GABA-A and glutamate NMDA receptors. An overview of the possible involvement of NASs in MDD, anxiety and pain is provided in this chapter. (C) 2015 S. Karger AG, Basel