Melatonin protects against oxidative organ injury in a rat model of sepsis


Sener G. , Toklu H., Kapucu C., Ercan F. , Erkanli G., Kacmaz A., ...More

SURGERY TODAY, vol.35, no.1, pp.52-59, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 1
  • Publication Date: 2005
  • Doi Number: 10.1007/s00595-004-2879-1
  • Title of Journal : SURGERY TODAY
  • Page Numbers: pp.52-59
  • Keywords: sepsis, melatonin, lipid peroxidation, glutathione, myeloperoxidase activity, ISCHEMIA-REPERFUSION, FREE-RADICALS, NITRIC-OXIDE, INFLAMMATION, GLUTATHIONE, DAMAGE, MYELOPEROXIDASE, ENDOTHELIUM, PERITONITIS, DYSFUNCTION

Abstract

Purpose. Based on the potent antioxidant effects of melatonin, we investigated the putative protective role of melatonin against sepsis-induced oxidative organ damage in rats.