Increased serum sialic acid in diabetic retinopathy of type 1 diabetes

ERASLAN M., ŞAHİN Ö., KAZOKOĞLU H. M., GOGAŞ YAVUZ D., ÇERMAN E., ÇELİKER H.

International Eye Science, cilt.13, sa.10, ss.1950-1952, 2013 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 10
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3980/j.issn.1672-5123.2013.10.02
  • Dergi Adı: International Eye Science
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1950-1952
  • Marmara Üniversitesi Adresli: Evet

Özet

AIM: To investigate the potential association between serum sialic acid and diabetic retinopathy and its several grades. METHODS: We studied the level of serum sialic acid in 70 patients. Thirty control vs 40 type 1 diabetics and with different levels of diabetic retinopathy as well. RESULTS: We found higher levels of serum sialic acid level in diabetics compared to control subjects (95.95±9.5 vs 45.05±19.91 mmoL/L, P=0.0001). We also observed a progressive rise in its concentration as the level of diabetic retinopathy increased (P<0.05) but the correlation was weak. Serum sialic acid level correlated positively with blood glucose level (r=0.67, P=0.0001). CONCLUSION: Increase in serum sialic acid levels seems to be related to the stage of the retinopathy and may help us to determine the extent of retinopathy in type 1 diabetic patients. But we think that we need more detailed studies to get a more precise conclusion.