Synthesis, characterization, and biological properties of composites of hydroxyapatite and hexagonal boron nitride

ÜNAL S., EKREN N., Sengil A. Z., OKTAR F. N., Irmak S., Oral O., ...Daha Fazla

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, cilt.106, sa.6, ss.2384-2392, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 106 Sayı: 6
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1002/jbm.b.34046
  • Dergi Adı: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2384-2392
  • Anahtar Kelimeler: composites, hydroxyapatite, bovine bone, hexagonal boron nitride, bioceramic, MECHANICAL-PROPERTIES, SINTERING TEMPERATURE, APATITE, NANOPARTICLES, NANOTUBES, BHA
  • Marmara Üniversitesi Adresli: Evet

Özet

Hydroxyapatite (HA), obtained from bovine bones, was successfully reinforced with hexagonal boron nitrite (h-BN). h-BN/HA composites, with BN content up to 1.5 wt %, were sintered at various temperatures between 1000 and 1300 degrees C, in air. Well-sintered samples were obtained after sintering at 1200 and 1300 degrees C. The presence of h-BN contributed to dense, fine, and well-crystallized microstructure. The results of X-ray diffraction analysis and FT-IR spectroscopy showed that the produced composites comprised biphasic beta-TCP/HCA (HCA: carbonate partially substituted HA). High values of mechanical properties were achieved, namely compression strength 155 MPa for the sample 0.5% h-BN/HA and Vickers microhardness of 716 HV for the samples 1.5% h-BN/HA, both sintered at 1300 degrees C. U2OS human bone osteosarcoma proliferation and cell viability showed no adverse effect in the presence of h-BN/HA, suggesting the potential use of the produced materials as safe biomaterials in bone tissue engineering. (C) 2017 Wiley Periodicals, Inc.