D-ALPHA-TOCOPHEROL CONTROL OF CELL-PROLIFERATION


AZZI A., BOSCOBOINIK D., CHATELAIN E., OZER N. , STAUBLE B.

MOLECULAR ASPECTS OF MEDICINE, cilt.14, sa.3, ss.265-271, 1993 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 14 Konu: 3
  • Basım Tarihi: 1993
  • Doi Numarası: 10.1016/0098-2997(93)90014-5
  • Dergi Adı: MOLECULAR ASPECTS OF MEDICINE
  • Sayfa Sayıları: ss.265-271

Özet

Uncontrolled cell growth is at the basis of neoplastic proliferation and arteriosclerotic lesions. In vitro proliferation of vascular smooth muscle cells, Balb c/3T3 fibroblasts, retinal neuroepithelial cells and neuroblastoma cells is inhibited by d-alpha-tocopherol. On the contrary Chinese hamster ovary cells, osteosarcoma cells and macrophages are not sensitive. PDGF-BB activated proliferation is highly d-alpha-tocopherol sensitive while lysophosphatidic acid induced growth is poorly inhibited. d-beta-Tocopherol, an analogue of d-alpha-tocopherol, with similar antioxidant properties, does not inhibit proliferation. Protein kinase C activity is inhibited by d-alpha-tocopherol but not by d-beta-tocopherol, suggesting a central role of this enzyme in the control of cell proliferation by d-alpha-tocopherol. Activation of the transcription activation complex AP-1 (but not NFkappaB) is prevented by d-alpha-tocopherol and not by d-beta-tocopherol.