Synthesis, structure elucidation and cytotoxic activities of 2,5-disubstituted-1,3,4-thiadiazole and 1,2,4-triazole-3-thione derivatives

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Kandemir L., KARAKUŞ S., ÖZBAŞ S., Rollas S., Akbuga J.

JOURNAL OF RESEARCH IN PHARMACY, cilt.26, sa.4, ss.941-953, 2022 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.29228/jrp.192
  • Dergi Adı: JOURNAL OF RESEARCH IN PHARMACY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.941-953
  • Anahtar Kelimeler: Acid hydrazide, cytotoxicity, 1,3,4-thiadiazole, 1,4-disubstituted thiosemicarbazide, 1,2,4-triazole-3-thione, ANTITUBERCULOSIS, 1-ACYLTHIOSEMICARBAZIDES, 1,3,4-THIADIAZOLES, ANTIBACTERIAL, SCAFFOLD
  • Marmara Üniversitesi Adresli: Evet

Özet

In this study, a series of 1,3,4-thiadiazole (1b-9b) and 1,2,4-triazole-3-thione (1c-9c) derivatives were synthesized. The reaction proses was carried out with the cyclocondensation of suitable 1,4-disubstituted thiosemicarbazide derivatives (1a-9a). The structures of the synthesized compounds were confirmed by the data obtained from elemental analysis, HPLC, UV, IR, H-1-NMR and MS spectra. All of the compounds were tested for their cytotoxic activities against L929 fibroblast cells by MTT method. It was determined that the tested compounds 1a-9a, 1b-9b and 1c-9c were not cytotoxic at the studied concentrations (5.0 mu g/mL and 10.0 mu g/mL) in L929 cell lines. Compounds 1a-c, 2a-c, 3a-c, 4a-c, 5a-c and 8a-c showed increased growth inhibition whereas compounds 6a-c, 7a-c and 9a-c showed decreased growth inhibition on L929 cell lines