Nivolumab in metastatic renal cell carcinoma: results from the Turkish Oncology Group Kidney Cancer Consortium database


Yekeduz E., Erturk I., Tural D., Karadurmus N., Karakaya S., Hizal M., ...More

FUTURE ONCOLOGY, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2021
  • Doi Number: 10.2217/fon-2021-0717
  • Title of Journal : FUTURE ONCOLOGY
  • Keywords: immunotherapy, kidney cancer, nivolumab, renal cell carcinoma, MANAGEMENT, EVEROLIMUS, SUNITINIB, OUTCOMES, THERAPY, BRAIN

Abstract

Lay abstract Nivolumab is an immune checkpoint inhibitor (ICI) that blocks the communication between T cells and cancer cells and instead activates T cells to fight against cancer. Metastatic renal cell carcinoma (mRCC) is one of the most susceptible tumors to ICIs. The Checkmate 025 trial showed the efficacy of nivolumab in patients with previously treated mRCC. In this real-world study, 173 patients with mRCC were treated with nivolumab in the second line and beyond. Nivolumab was effective in the real-world setting without additional safety concerns.