Oxytocin protects against sepsis-induced multiple organ damage: Role of neutrophils

Iseri S., Sener G., Saglam B., Gedik N., Ercan F., Yegen B.

JOURNAL OF SURGICAL RESEARCH, cilt.126, sa.1, ss.73-81, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 126 Sayı: 1
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.jss.2005.01.021
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.73-81
  • Anahtar Kelimeler: oxytocin, sepsis, myeloperoxidase, glutathione, TNF-alpha, MELATONIN TREATMENT, OXIDATIVE STRESS, GROWTH-HORMONE, SEPTIC SHOCK, INFLAMMATION, RAT, INJURY, PERITONITIS, LIPOPOLYSACCHARIDE, GLUTATHIONE
  • Marmara Üniversitesi Adresli: Evet

Özet

Background. Sepsis, commonly associated with enhanced generation of reactive oxygen metabolites, leads to multiple organ dysfunctions. The neurohypophyseal hormone oxytocin (OT), released during social contact, was recently shown to modulate the immune and inflammatory processes. We investigated the protective role of OT against sepsis-induced pelvic inflammation.