Oxytocin protects against sepsis-induced multiple organ damage: Role of neutrophils

Iseri S., Sener G., Saglam B., Gedik N., Ercan F., Yegen B.

JOURNAL OF SURGICAL RESEARCH, vol.126, no.1, pp.73-81, 2005 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 126 Issue: 1
  • Publication Date: 2005
  • Doi Number: 10.1016/j.jss.2005.01.021
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.73-81
  • Keywords: oxytocin, sepsis, myeloperoxidase, glutathione, TNF-alpha, MELATONIN TREATMENT, OXIDATIVE STRESS, GROWTH-HORMONE, SEPTIC SHOCK, INFLAMMATION, RAT, INJURY, PERITONITIS, LIPOPOLYSACCHARIDE, GLUTATHIONE
  • Marmara University Affiliated: Yes

Abstract

Background. Sepsis, commonly associated with enhanced generation of reactive oxygen metabolites, leads to multiple organ dysfunctions. The neurohypophyseal hormone oxytocin (OT), released during social contact, was recently shown to modulate the immune and inflammatory processes. We investigated the protective role of OT against sepsis-induced pelvic inflammation.