D-ALPHA-TOCOPHEROL INHIBITS LOW-DENSITY-LIPOPROTEIN INDUCED PROLIFERATION AND PROTEIN-KINASE-C ACTIVITY IN VASCULAR SMOOTH-MUSCLE CELLS

OZER, NESRİN; PALOZZA, P; BOSCOBOINIK, D; AZZI, A

doi:10.1016/0014-5793(93)81592-n

D-ALPHA-TOCOPHEROL INHIBITS LOW-DENSITY-LIPOPROTEIN INDUCED PROLIFERATION AND PROTEIN-KINASE-C ACTIVITY IN VASCULAR SMOOTH-MUSCLE CELLS

Atıf İçin Kopyala

OZER N., PALOZZA P., BOSCOBOINIK D., AZZI A.

FEBS LETTERS, cilt.322, sa.3, ss.307-310, 1993 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 322 Sayı: 3
Basım Tarihi: 1993
Doi Numarası: 10.1016/0014-5793(93)81592-n
Dergi Adı: FEBS LETTERS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.307-310
Marmara Üniversitesi Adresli: Evet

Özet

Native and malondialdehyde modified low density lipoproteins have been shown to stimulate smooth muscle cell proliferation (A7r5) in vitro. The stimulation is associated with an increase of protein kinase C activity. d-alpha-Tocopherol, at physiological concentrations, has been found to inhibit both protein kinase C activity and cell proliferation.