D-ALPHA-TOCOPHEROL INHIBITS LOW-DENSITY-LIPOPROTEIN INDUCED PROLIFERATION AND PROTEIN-KINASE-C ACTIVITY IN VASCULAR SMOOTH-MUSCLE CELLS


OZER N. , PALOZZA P., BOSCOBOINIK D., AZZI A.

FEBS LETTERS, cilt.322, sa.3, ss.307-310, 1993 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 322 Konu: 3
  • Basım Tarihi: 1993
  • Doi Numarası: 10.1016/0014-5793(93)81592-n
  • Dergi Adı: FEBS LETTERS
  • Sayfa Sayıları: ss.307-310

Özet

Native and malondialdehyde modified low density lipoproteins have been shown to stimulate smooth muscle cell proliferation (A7r5) in vitro. The stimulation is associated with an increase of protein kinase C activity. d-alpha-Tocopherol, at physiological concentrations, has been found to inhibit both protein kinase C activity and cell proliferation.