D-ALPHA-TOCOPHEROL INHIBITS LOW-DENSITY-LIPOPROTEIN INDUCED PROLIFERATION AND PROTEIN-KINASE-C ACTIVITY IN VASCULAR SMOOTH-MUSCLE CELLS


OZER N. , PALOZZA P., BOSCOBOINIK D., AZZI A.

FEBS LETTERS, vol.322, no.3, pp.307-310, 1993 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 322 Issue: 3
  • Publication Date: 1993
  • Doi Number: 10.1016/0014-5793(93)81592-n
  • Title of Journal : FEBS LETTERS
  • Page Numbers: pp.307-310

Abstract

Native and malondialdehyde modified low density lipoproteins have been shown to stimulate smooth muscle cell proliferation (A7r5) in vitro. The stimulation is associated with an increase of protein kinase C activity. d-alpha-Tocopherol, at physiological concentrations, has been found to inhibit both protein kinase C activity and cell proliferation.