Caffeic acid phenethyl ester (CAPE) prevents methotrexate-induced hepatorenal oxidative injury in rats

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Cakir T., Ozkan E., Dulundu E., Topaloglu U., Sehirli A. O., ERCAN F., ...More

JOURNAL OF PHARMACY AND PHARMACOLOGY, vol.63, no.12, pp.1566-1571, 2011 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 63 Issue: 12
• Publication Date: 2011
• Doi Number: 10.1111/j.2042-7158.2011.01359.x
• Journal Name: JOURNAL OF PHARMACY AND PHARMACOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.1566-1571
• Keywords: caffeic acid phenethyl ester, kidney, liver, methotrexate, oxidative damage, INDUCED NEPHROTOXICITY, LIPID-PEROXIDATION, STRESS, ANTIOXIDANT, KIDNEY, PROPOLIS, CELLS, LIVER, MYELOPEROXIDASE, PHARMACOLOGY
• Marmara University Affiliated: Yes

Abstract

Objectives This study aimed to investigate the antioxidant and anti-inflammatory effects of caffeic acid phenethyl ester (CAPE) on the methotrexate (MTX)-induced hepatorenal oxidative damage in rats.