Caffeic acid phenethyl ester (CAPE) prevents methotrexate-induced hepatorenal oxidative injury in rats


Cakir T., Ozkan E., Dulundu E. , Topaloglu U., Sehirli A. O. , ERCAN F. , ...More

JOURNAL OF PHARMACY AND PHARMACOLOGY, vol.63, no.12, pp.1566-1571, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 12
  • Publication Date: 2011
  • Doi Number: 10.1111/j.2042-7158.2011.01359.x
  • Title of Journal : JOURNAL OF PHARMACY AND PHARMACOLOGY
  • Page Numbers: pp.1566-1571
  • Keywords: caffeic acid phenethyl ester, kidney, liver, methotrexate, oxidative damage, INDUCED NEPHROTOXICITY, LIPID-PEROXIDATION, STRESS, ANTIOXIDANT, KIDNEY, PROPOLIS, CELLS, LIVER, MYELOPEROXIDASE, PHARMACOLOGY

Abstract

Objectives This study aimed to investigate the antioxidant and anti-inflammatory effects of caffeic acid phenethyl ester (CAPE) on the methotrexate (MTX)-induced hepatorenal oxidative damage in rats.