Research Information System
3rd International Eurasian Conference on Science, Engineering and Technology (EurasianSciEnTech 2021), Ankara, Turkey, 15 - 17 December 2021, pp.733-737, (Full Text)
Wound healing is a complex and very important research area that requires different types of materials for
specific conditions. Today, developing new materials for specific wound types is one of the most attractive
issues for scientists. In this study, CMC / PEG / GO (rGO) hydrogels were produced, characterized and their
wound healing potentials were investigated. Graphene oxide (GO) was successfully synthesized using a
modified Hummers method. Then, green reduction of GO was succeeded by using Laurus nobilis extract to
obtain rGO. Finally, GO (rGO) in different ratios (0%, 10% and 40% v/v) were added to a mixture of CMC
and PEG and hydrogels were formed with addition of citric acid (CA) as crosslinker. For the preparation of
hydrogels certain parameters were changed and effect of these changes on properties and swelling behaviour
of hydrogels were examined. For this purpose crosslinker CA amount was changed from 10%, 15%. to 25%
w/w, and PEG amount from 10%, 20%, 50% to 100% w/w were investigated. All hydrogels were prepared
successfully. They had enough mechanical strength and high swelling ratios up to 2771% which is quite ideal
in wound dressings. Furthermore, physical and chemical characterizations of these hydrogels, GO and rGO
were realized by employing FT-IR and SEM analyses and structures were confirmed. Hydrogel-cell
interactions will be investigated with L929 cells and toxicity will be determined by MTT tests and GO (rGO)
concentration dependent toxicity was expected. Prepared hydrogels with high swelling ratios and enough pores
for cell attachment and proliferation makes them promising candidates to be used in wound dressing
applications.