Arginase activity and nitric oxide levels in patients with obstructive sleep apnea syndrome


YÜKSEL M. , Okur H. K. , Pelin Z., VELİOĞLU ÖĞÜNÇ A. , ÖZTÜRK L.

CLINICS, vol.69, no.4, pp.247-252, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.6061/clinics/2014(04)05
  • Title of Journal : CLINICS
  • Page Numbers: pp.247-252
  • Keywords: Obstructive Sleep Apnea Syndrome, Nitric Oxide, Arginase Activity, Cardiovascular Diseases, POSITIVE AIRWAY PRESSURE, C-REACTIVE PROTEIN, OXIDATIVE STRESS, BAROREFLEX SENSITIVITY, VASCULAR DYSFUNCTION, IMPROVES, SYNTHASE, PATHWAY, CELLS

Abstract

OBJECTIVE: Obstructive sleep apnea syndrome is characterized by repetitive obstruction of the upper airways, and it is a risk factor for cardiovascular diseases. There have been several studies demonstrating low levels of nitric oxide in patients with obstructive sleep apnea syndrome compared with healthy controls. In this study, we hypothesized that reduced nitric oxide levels would result in high arginase activity. Arginase reacts with L-arginine and produces urea and L-ornithine, whereas L-arginine is a substrate for nitric oxide synthase, which produces nitric oxide.