Effectiveness of Recombinant Human Growth Hormone for Pharyngocutaneous Fistula Closure


Kucuk N., Sari M., Midi A., YUMUŞAKHUYLU A. C., Findik O., BİNNETOĞLU A.

CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY, cilt.8, sa.4, ss.390-395, 2015 (SCI-Expanded) identifier

Özet

Objectives. In laryngeal cancer, which comprises 25% of head and neck cancer, chemotherapy has come into prominence with the increase in organ-protective treatments. With such treatment, salvage surgery has increased following recurrence; the incidence of pharyngocutaneous fistula has also increased in both respiratory and digestive system surgery We investigated the effects of recombinant human growth hormone on pharyngocutaneous fistula closure in Sprague-Dawley rats, based on an increase in amino acid uptake and protein synthesis for wound healing, an increase in mitogenesis, and enhancement of collagen formation by recombinant human growth hormone.