Effectiveness of Recombinant Human Growth Hormone for Pharyngocutaneous Fistula Closure

Kucuk N., Sari M., Midi A., YUMUŞAKHUYLU A. C. , Findik O., BİNNETOĞLU A.

CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY, cilt.8, sa.4, ss.390-395, 2015 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 8 Konu: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3342/ceo.2015.8.4.390
  • Sayfa Sayıları: ss.390-395


Objectives. In laryngeal cancer, which comprises 25% of head and neck cancer, chemotherapy has come into prominence with the increase in organ-protective treatments. With such treatment, salvage surgery has increased following recurrence; the incidence of pharyngocutaneous fistula has also increased in both respiratory and digestive system surgery We investigated the effects of recombinant human growth hormone on pharyngocutaneous fistula closure in Sprague-Dawley rats, based on an increase in amino acid uptake and protein synthesis for wound healing, an increase in mitogenesis, and enhancement of collagen formation by recombinant human growth hormone.