Phoenixin 14 ameloriates pancreatic injury in streptozotocin-induced diabetic rats by alleviating oxidative burden

ÖZDEMİR KUMRAL Z. N., Sen E., Yapici H. B., Atakul N., Domruk O. F., Aldag Y., ...Daha Fazla

JOURNAL OF PHARMACY AND PHARMACOLOGY, cilt.74, sa.11, ss.1651-1659, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 74 Sayı: 11
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1093/jpp/rgac055
  • Dergi Adı: JOURNAL OF PHARMACY AND PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1651-1659
  • Anahtar Kelimeler: inflammation, insulin, gastric emptying, glucose, free radicals, MPO, ORAL GLUCOSE-TOLERANCE, PEPTIDE, TESTOSTERONE, MODULATION, NESFATIN-1, EXPRESSION, SECRETION, STRESS, DAMAGE, SITES
  • Marmara Üniversitesi Adresli: Evet

Özet

Phoenixin-14 (PNX) is a neuropeptide that has been shown to prevent oxidative damage and stimulates insulin secretion. We investigated the effects of PNX on pancreatic injury induced by streptozotocin (STZ), and nicotinamide (NAD). Male Sprague-Dawley rats, in control (C) and diabetic (STZ) groups, were treated with either saline, or PNX (0.45 nmol/kg, or 45 nmol/kg) daily for 3 days 1 week after STZ injection. Fasting blood glucose (FBG) and gastric emptying rate (GER) were measured. Tissue and blood samples were collected. PNX treatments prevented pancreatic damage and beta cell loss. Increased luminol and lucigenin levels in the pancreas, ileum and liver tissues of STZ groups were alleviated by PNX treatment in pancreatic and ileal tissues. PNX0.45 decreased FBG without any change in insulin blood level and pancreatic mRNA. GER increased in all diabetic rats while PNX0.45 delayed GER only in the C group. PNX diminishes pancreatic damage and lowers FBG by reducing oxidative load.