Interstitial Mycosis Fungoides With Lichen Sclerosus-Like Clinical and Histopathological Features


Tekin B., Kempf W., SEÇKİN GENÇOSMANOĞLU D. , Ergun T., Yucelten D., Demirkesen C.

AMERICAN JOURNAL OF DERMATOPATHOLOGY, vol.38, no.2, pp.138-143, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.1097/dad.0000000000000406
  • Title of Journal : AMERICAN JOURNAL OF DERMATOPATHOLOGY
  • Page Numbers: pp.138-143
  • Keywords: interstitial mycosis fungoides, lichen sclerosus, T-CELL, CUTANEOUS LYMPHOMAS, GRANULOMA-ANNULARE, ET-ATROPHICUS, DIAGNOSIS, LESIONS

Abstract

Mycosis fungoides (MF) simulates a variety of dermatologic disorders histopathologically and clinically, well deserving the designation of a great mimicker. Interstitial MF is a rare, but well-recognized histopathological variant resembling the interstitial form of granuloma annulare or the inflammatory phase of morphea. From a clinical standpoint, MF can have a wide array of manifestations, including an anecdotal presentation with lesions clinically suggestive of lichen sclerosus (LS). We herein report a 25-year-old man with a history of patch-stage MF who later developed widespread LS-like lesions histopathologically consistent with interstitial MF. In some biopsies, additional features resembling LS were discerned. We think that our case might represent a unique variant of interstitial MF presenting with LS-like lesions. The diagnostic challenge arising from this uncommon presentation is discussed together with review of the literature.