Comparative effects of vitamin D and methylprednisolone against ischemia/reperfusion injury of rabbit spinal cords

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Gurer B., Karakoc A., Bektasoglu P. K., Kertmen H., Kanat M. A., Arikok A. T., ...More

EUROPEAN JOURNAL OF PHARMACOLOGY, vol.813, pp.50-60, 2017 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 813
• Publication Date: 2017
• Doi Number: 10.1016/j.ejphar.2017.07.028
• Journal Name: EUROPEAN JOURNAL OF PHARMACOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.50-60
• Keywords: Calcitriol, Ischemia/reperfusion injury, Methylprednisolone, Neuroprotection, Spinal cord injury, Vitamin D, ISCHEMIA-REPERFUSION INJURY, NEURONAL CELL-DEATH, QUALITY-OF-LIFE, 1,25-DIHYDROXYVITAMIN D-3, LIPID-PEROXIDATION, ISCHEMIC/REPERFUSION INJURY, XANTHINE-OXIDASE, FLUID DRAINAGE, D-RECEPTOR, D HORMONE
• Marmara University Affiliated: No

Abstract

Introduction: Recent studies have demonstrated the neuroprotective and immunomodulatory effects of 1,25-dihydroxyvitamin D3 (calcitriol), but no previous study has examined these effects on spinal cord ischemia/reperfusion (I/R) injury. Therefore, the present study aimed to evaluate whether calcitriol protects the spinal cord from I/R injury.