Comparative effects of vitamin D and methylprednisolone against ischemia/reperfusion injury of rabbit spinal cords

Gurer B., Karakoc A., Bektasoglu P. K., Kertmen H., Kanat M. A., Arikok A. T., ...Daha Fazla

EUROPEAN JOURNAL OF PHARMACOLOGY, cilt.813, ss.50-60, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 813
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.ejphar.2017.07.028
  • Dergi Adı: EUROPEAN JOURNAL OF PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.50-60
  • Anahtar Kelimeler: Calcitriol, Ischemia/reperfusion injury, Methylprednisolone, Neuroprotection, Spinal cord injury, Vitamin D, ISCHEMIA-REPERFUSION INJURY, NEURONAL CELL-DEATH, QUALITY-OF-LIFE, 1,25-DIHYDROXYVITAMIN D-3, LIPID-PEROXIDATION, ISCHEMIC/REPERFUSION INJURY, XANTHINE-OXIDASE, FLUID DRAINAGE, D-RECEPTOR, D HORMONE
  • Marmara Üniversitesi Adresli: Hayır

Özet

Introduction: Recent studies have demonstrated the neuroprotective and immunomodulatory effects of 1,25-dihydroxyvitamin D3 (calcitriol), but no previous study has examined these effects on spinal cord ischemia/reperfusion (I/R) injury. Therefore, the present study aimed to evaluate whether calcitriol protects the spinal cord from I/R injury.