Tacrolimus-Eluting Suture Inhibits Neointimal Hyperplasia: An Experimental In Vivo Study in Rats


AK K. , AK E. , Dericioglu O., Çanak T., Akbuga J., ÖZKAN N., ...Daha Fazla

EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, cilt.53, sa.3, ss.431-437, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 53 Konu: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.ejvs.2016.11.027
  • Dergi Adı: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
  • Sayfa Sayıları: ss.431-437

Özet

Objective/Background: Neointimal hyperplasia (NIH) remains one of the leading causes of graft failure after vascular anastomoses. Cytotoxic drugs, such as rapamycin and tacrolimus, have been shown to inhibit the development of NIH. In this study, the aim was to test the impact of a sustained releasing tacrolimus-chitosan-eluting suture on the development of NIH in a rat model.