Synthesis of some novel azo derivatives of 3,5-dimethly-1-(2-hydroxyethyl)pyrazole as potent analgesic agents
ARCHIV DER PHARMAZIE, cilt.339, sa.5, ss.267-272, 2006 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 339 Sayı: 5
- Basım Tarihi: 2006
- Doi Numarası: 10.1002/ardp.200500202
- Dergi Adı: ARCHIV DER PHARMAZIE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.267-272
- Anahtar Kelimeler: phenylazo compounds, pyrazoles, thiadiazoles, triazoles, analgesic activity, ANTICONVULSANT ACTIVITY, BIOLOGICAL EVALUATION, ANTITUBERCULOSIS ACTIVITY, 1,3,4-THIADIAZOLE, 1,2,4-TRIAZOLE, ANALOGS, INDOLE, RATS, MICE
- Marmara Üniversitesi Adresli: Evet
Özet
A series of 1-(2-hydroxyethyl)-3,5-dimethylpyrazolylazo derivatives, incorporating thiosemicarbazide 2a-c, 1,3,4-thiadiazole 3a-c, and 1,2,4-triazole-3-thione 4a-c were synthesized. The structure of these novel synthesized compounds 2a-c, 3a-c, and 4a-c was confirmed by spectral analysis. All these compounds were screened for their analgesic activity. Hot-plate and tail-immersion tests were used for the determination of the analgesic activity. Morphine, an analgesic through both spinal and supraspinal pathways, was used as a standard test drug. All compounds were administered at a dose of 100 mg/kg i.p. Among the compounds, 2-(butylamino)-5-[((1-(2-hydroxyethyl)-3,5-dimethylpyrazole-4-yl)azo)phenyl]-1,3,4-thiadiazole 3a and 4-[((1-(2-hydroxyethyl)-3,5dimethylpyrazole-4-yl)azo)phenyl]-4-(2-phenethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 4c showed analgesic effects in both tests. Especially 4c exerted strong analgesia starting at 30 min after injection.