Effects of volatile anesthetics on store-operated Ca2+ influx in airway smooth muscle


Pabelick C., Ay B., Prakash Y., Sieck G.

ANESTHESIOLOGY, vol.101, no.2, pp.373-380, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 101 Issue: 2
  • Publication Date: 2004
  • Doi Number: 10.1097/00000542-200408000-00018
  • Title of Journal : ANESTHESIOLOGY
  • Page Numbers: pp.373-380

Abstract

Background: In airway smooth muscle (ASM), volatile anesthetics deplete sarcoplasmic reticulum (SR) Ca2+ stores by increasing Ca2+ "leak." Accordingly, SR replenishment becomes dependent on Ca2+ influx. Depletion of SR Ca2+ stores triggers Ca2+ influx via specific plasma membrane channels, store-operated Ca2+ channels (SOCC). We hypothesized that anesthetics inhibit SOCC triggered by increased SR Ca2+ "leak," preventing SR replenishment and enhancing ASM relaxation.