Effects of volatile anesthetics on store-operated Ca2+ influx in airway smooth muscle

Pabelick C., Ay B., Prakash Y., Sieck G.

ANESTHESIOLOGY, cilt.101, sa.2, ss.373-380, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 101 Konu: 2
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1097/00000542-200408000-00018
  • Sayfa Sayıları: ss.373-380


Background: In airway smooth muscle (ASM), volatile anesthetics deplete sarcoplasmic reticulum (SR) Ca2+ stores by increasing Ca2+ "leak." Accordingly, SR replenishment becomes dependent on Ca2+ influx. Depletion of SR Ca2+ stores triggers Ca2+ influx via specific plasma membrane channels, store-operated Ca2+ channels (SOCC). We hypothesized that anesthetics inhibit SOCC triggered by increased SR Ca2+ "leak," preventing SR replenishment and enhancing ASM relaxation.