Biological Activities, Phytochemical Analysis, and Preparation of Nanoparticle Formulations of <i>Hypericum cardiophyllum</i> Boiss

Ermanoğlu M., Niar S. H. N., Taşkın D., Şahin T., Kılıç Ö., Salihi E., ...Daha Fazla

CHEMISTRYSELECT, cilt.10, sa.40, 2025 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 40
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1002/slct.202504578
  • Dergi Adı: CHEMISTRYSELECT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core
  • Anahtar Kelimeler: Biological activity, Drug delivery system, H. cardiophyllum, HPLC-DAD, Nanoparticle
  • Marmara Üniversitesi Adresli: Evet

Özet

The aim of this research was to investigate the in vitro biological activities of Hypericum cardiophyllum extracts, to develop nanoparticle formulations from bioactive extract, to analyze the phytochemical contents of the extract and formulation qualitatively and quantitatively using HPLC-DAD. The findings of this study showed that the methanol extract-loaded nanoparticle had stronger anticholinesterase activity than the crude extract. The methanol extract (31.27 µg/mg extract) and the extract-loaded nanoparticle (10.45 µg/mg extract) were analyzed to contain the highest amount of rutin compound. Considering the advantages of nanoparticles such as controlled release and fewer side effects, it is thought that the methanol-loaded nanoparticle developed in this study can be used as a drug/pharmaceutical raw material in the future.