Can Atopic Diseases be Differentiated from Hyper IgE Syndrome by Serum IgE and Blood Eosinophil Levels?

Kiykim A., Yuce E. G., Baris E., Nain E., KELEŞ S., Akturk H., ...More

ASTIM ALLERJI IMMUNOLOJI, vol.15, no.2, pp.73-81, 2017 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.21911/aai.13
  • Journal Name: ASTIM ALLERJI IMMUNOLOJI
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.73-81
  • Keywords: Atopic diseases, child, eosinophil, hyper IgE syndrome, IgE, ALLERGIC SENSITIZATION, HYPERIMMUNOGLOBULIN-E, RECURRENT INFECTIONS, CLINICAL PHENOTYPE, DERMATITIS, DOCK8, DEFICIENCY, MUTATIONS, ECZEMA, MECHANISMS
  • Marmara University Affiliated: Yes

Abstract

Objective: High serum IgE and eosinophil counts are laboratory features of severe atopic dermatitis (AD), persistent food allergies and severe allergic asthma as well as some primary immune deficiencies (PID), especially hyperIgE syndrome (HIES). Our objective was to define cut-off values to discriminate atopic diseases and HIES by comparing serum IgE, eosinophil levels, allergen sensitizations among patients with AD, IgE-mediated food allergy, allergic asthma and/or rhinitis, chronic granulomatous disease and HIES.