The effects of TNF alpha inhibition on plasma fibrinolytic balance in patients with chronic inflammatory rheumatical disorders

Agirbasli M., Inanc N., Baykan O. A., Direskeneli H.

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, cilt.24, sa.5, ss.580-583, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 5
  • Basım Tarihi: 2006
  • Dergi Adı: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.580-583
  • Anahtar Kelimeler: TNF alpha inhibition, plasma fibrinolytic balance, PAI-1, t-PA, NECROSIS-FACTOR-ALPHA, PLASMINOGEN-ACTIVATOR INHIBITOR-1, CORONARY-HEART-DISEASE, ENDOTHELIAL-CELLS, MONOCLONAL-ANTIBODY, ARTHRITIS PATIENTS, RAPID INHIBITOR, INFLIXIMAB, ATHEROSCLEROSIS, METHOTREXATE
  • Marmara Üniversitesi Adresli: Evet

Özet

Objectives. Recent studies support an inflammatory basis for atherosclerosis. Patients with chronic inflammatory rheumatical disorders are at increased risk for cardiovascular events, and this can be partially attributed to the inhibition of fibrinolytic system. TNF alpha inhibitors such as.infliximab are shown to retard the progression of inflammatory arthritides. In this study, we investigated the effects of infliximab on plasma fibrinolytic parameters.