Effect of harmane on mononeuropathic pain in rats

Aricioglu F., Korcegez E., Ozyalcin S.

AGMATINE AND IMIDAZOLINES: THEIR NOVEL RECEPTORS AND ENZYMES, vol.1009, pp.180-184, 2003 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 1009
  • Publication Date: 2003
  • Doi Number: 10.1196/annals.1304.021
  • Journal Name: AGMATINE AND IMIDAZOLINES: THEIR NOVEL RECEPTORS AND ENZYMES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.180-184
  • Keywords: harmane, chronic constriction injury, imidazoline, allodynia, RECEPTOR AGONIST, MOXONIDINE
  • Marmara University Affiliated: No

Abstract

This study was designed to investigate the effect of the endogenous beta-carboline, harmane, on neuropathic pain produced by chronic constriction injury (CCI) of the sciatic nerve. Thermal allodynia evaluations were made preoperatively, postoperatively on the fifteenth day, and after harmane administration. Harmane (1, 2.5, 5, 10, or 20 mg/kg) was administered intraperitoneally for 5 days beginning from postoperative day 15. Treatment with harmane had a profound anti-allodynic effect in a dose-dependent manner. In conclusion, harmane might provide a new approach to treatment of neuropathic pain.