Changes in transforming growth factor-beta 1 in gingival crevicular fluid following periodontal surgery

Kuru L. , Griffiths G., Petrie A., Olsen I.

JOURNAL OF CLINICAL PERIODONTOLOGY, cilt.31, sa.7, ss.527-533, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Konu: 7
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1111/j.1600-051x.2004.00521.x
  • Sayfa Sayıları: ss.527-533


Objectives: Growth factors play a major part in wound healing, including in the periodontium. However, the presence of growth factors in gingival crevicular fluid (GCF) in humans during periodontal wound healing has not yet been determined. Our hypothesis is that such factors are present in GCF and that changes in their levels might be of value as a prognostic marker of wound-healing activity and therapeutic progress following periodontal surgery. The aim of this study was therefore to measure transforming growth factor-beta1 (TGF-beta1) in GCF collected from sites that have undergone guided tissue regeneration (GTR) and conventional flap (CF) surgery and to compare these with GCF collected from unaffected healthy sites.