Evaluation of GAD67 immunoreactivity in the region of substantia nigra pars reticulata in resistance to development of convulsive seizure in genetic absence epilepsy rats

GÜLÇEBİ İDRİZ OĞLU M., Akman O., Carcak N., Karamahmutoglu T., ONAT F.

NORTHERN CLINICS OF ISTANBUL, vol.3, no.3, pp.161-167, 2016 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 3 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.14744/nci.2016.16056
  • Journal Name: NORTHERN CLINICS OF ISTANBUL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.161-167
  • Keywords: Epilepsy, GAERS, gamma-aminobutyric acid, immunohistochemistry, GAMMA-AMINOBUTYRIC-ACID, TEMPORAL-LOBE EPILEPSY, ELECTRICAL-STIMULATION, MECHANISMS, THRESHOLD, NEURONS, MODEL
  • Marmara University Affiliated: Yes

Abstract

OBJECTIVE: Nonconvulsive absence epilepsy and convulsive epilepsy seizures are rarely seen in the same patient. It has been demonstrated that there is a resistance to development of convulsive seizures in genetic absence epilepsy models. The present study investigated glutamic acid decarboxylase (GAD) immunoreactivity in the brain region related to the interaction of these two seizure types, namely substantia nigra pars reticulata (SNR) subregions, SNRantenor and SNRpostenor.