Tracing the Spectrum of Inborn Errors of Immunity from Past to Present

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BARIŞ S., Chatila T. A.

Turkish Journal of Immunology, vol.12, no.1, pp.1-5, 2024 (ESCI, Scopus, TRDizin) identifier identifier

  • Publication Type: Article / Editorial Material
  • Volume: 12 Issue: 1
  • Publication Date: 2024
  • Doi Number: 10.4274/tji.galenos.2024.00001
  • Journal Name: Turkish Journal of Immunology
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1-5
  • Keywords: diagnosis, Inborn errors of immunity, outcome, primary immune deficiencies, treatment
  • Open Archive Collection: AVESIS Open Access Collection
  • Marmara University Affiliated: Yes

Abstract

Human inborn errors of immunity (IEI) constitute a constellation of genetic disorders with profound implications for immune system function, leading to recurrent infections, immune dysregulations, and malignancies. The field of IEI has undergone a tremendous evolution over the course of seventy years, with substantial strides in comprehending the clinical and immunological aspects of monogenic disorders. Furthermore, these endeavors have synergized with innovative therapeutic modalities, forging a trajectory toward enhanced patient care. These advances promise to favorably transform the outcomes of many IEI to provide patients with increased life expectancy and improved quality of life. In this special issue of the Turkish Journal of Immunology, we will survey some recent advances in the field of IEI with a focus on disease pathogenesis and outcomes.