The Effects of Riluzole on Neurological, Brain Biochemical, and Histological Changes in Early and Late Term of Sepsis in Rats

Toklu H. Z., Uysal M. K., KABASAKAL L., ŞİRVANCI S., ERCAN F., Kaya M.

JOURNAL OF SURGICAL RESEARCH, cilt.152, sa.2, ss.238-248, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 152 Sayı: 2
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.jss.2008.03.013
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.238-248
  • Anahtar Kelimeler: riluzole, glutamate, sepsis, encephalopathy, blood brain barrier, antioxidant, neuroprotective, MDA, glutathione, CRITICAL ILLNESS POLYNEUROPATHY, OXIDATIVE STRESS, NEUROPROTECTIVE AGENT, ATTENUATES EDEMA, TNF-ALPHA, GLUTAMATE, INJURY, DYSFUNCTION, MODEL, LIPOPOLYSACCHARIDE
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective. One of the underlying mechanisms of sepsis is thought to be the oxidative damage due to the generation of free radicals. Glutamate, the major excitatory amino acid in the brain, is known to play an important role in blood brain barrier (BBB) permeability, brain edema, and oxidative damage in pathological conditions. Riluzole, a glutamate release inhibitor, has been shown to have neuroprotective effects in several animal models. The aim of our study was to investigate the putative protective effect of riluzole against sepsis-induced brain injury.