Low dose MK-801 protects against iron-induced oxidative changes in a rat model of focal epilepsy

Kucukkaya B., Aker R., Yuksel M., Onat F., Yalcin A. S.

BRAIN RESEARCH, cilt.788, ss.133-136, 1998 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 788
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1016/s0006-8993(97)01544-8
  • Dergi Adı: BRAIN RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.133-136
  • Anahtar Kelimeler: chemiluminescence, MK-801, iron-induced epilepsy, oxidative changes, EPILEPTIFORM DISCHARGES, LIPID-PEROXIDATION, PHENCYCLIDINE, BRAIN, ANTAGONISTS, INJECTION, RADICALS, STRESS
  • Marmara Üniversitesi Adresli: Evet

Özet

We have used chemiluminescence measurements to examine the relationship between free radical formation and excitotoxicity in a post-traumatic epilepsy model. For this purpose, seven days after injecting iron in rat brain cortices, we measured luminol-and lucigenin-enhanced chemiluminescence in different brain regions (ipsilateral cortex, contralateral cortex, hypothalamus and hippocampus), In all brain regions (except contralateral cortices) both luminol- and lucigenin-enhanced chemiluminescence were increased in iron-injected group compared to saline-injected control group. These increases returned to control values in iron-injected rats pretreated with MK-801. Our results suggest that both free radicals and excitatory amino acids play important roles in the development of post-traumatic epilepsy and that MK-801 has protective effects against iron-induced chemiluminescence formation. (C) 1998 Elsevier Science B.V.