Assessment of disease activity in large-vessel vasculitis: Results of an international delphi exercise

Aydin S. Z., Direskeneli H., Merkel P. A.

Journal of Rheumatology, vol.44, no.12, pp.1928-1932, 2017 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 12
  • Publication Date: 2017
  • Doi Number: 10.3899/jrheum.161269
  • Journal Name: Journal of Rheumatology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1928-1932
  • Keywords: VASCULITIS, TAKAYASU ARTERITIS, GIANT CELL ARTERITIS, LARGE VESSEL, OUTCOMES, GIANT-CELL ARTERITIS, TAKAYASUS-ARTERITIS, FEATURES, TURKEY
  • Marmara University Affiliated: Yes

Abstract

Copyright © 2017. All rights reserved.Objective. To arrive at consensus for candidate outcomes for disease activity assessment in largevessel vasculitis (LVV) in clinical trials. Methods.A Delphi survey including 99 items was circulated among international experts for 3 rounds. Results. Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging. Conclusion. This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes.