Neurogenesis is Enhanced in Young Rats with Genetic Absence Epilepsy: An Immuno-electron Microscopic Study

KAYA Ö. T., Moore C., Meshul C. K., Gursoy D., ONAT F., ŞİRVANCI S.

TURKISH NEUROSURGERY, cilt.31, sa.4, ss.623-633, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.5137/1019-5149.jtn.31996-20.2
  • Dergi Adı: TURKISH NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.623-633
  • Anahtar Kelimeler: Doublecortin, GABA, VGLUT-1, GAERS, Immunoelectron microscopy, GLUTAMATERGIC GRANULE CELLS, DENTATE GYRUS, GABAERGIC PHENOTYPE, STATUS-EPILEPTICUS, ADULT, NEURONS, DOUBLECORTIN, GABA, EXPRESSION, BORN
  • Marmara Üniversitesi Adresli: Evet

Özet

AIM: To investigate neurogenesis in both adult and 3-week-old genetic absence epilepsy rats from Strasbourg (GAERS) to determine if newly formed neurons within the dentate gyrus (DG) form synaptic contacts with GABAergic (gamma aminobutyric acid) and glutamatergic nerve terminals and compared to the control (non-GAERS) Wistar rats.