Neurogenesis is Enhanced in Young Rats with Genetic Absence Epilepsy: An Immuno-electron Microscopic Study

KAYA Ö. T., Moore C., Meshul C. K., Gursoy D., ONAT F., ŞİRVANCI S.

TURKISH NEUROSURGERY, vol.31, no.4, pp.623-633, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.5137/1019-5149.jtn.31996-20.2
  • Journal Name: TURKISH NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.623-633
  • Keywords: Doublecortin, GABA, VGLUT-1, GAERS, Immunoelectron microscopy, GLUTAMATERGIC GRANULE CELLS, DENTATE GYRUS, GABAERGIC PHENOTYPE, STATUS-EPILEPTICUS, ADULT, NEURONS, DOUBLECORTIN, GABA, EXPRESSION, BORN
  • Marmara University Affiliated: Yes

Abstract

AIM: To investigate neurogenesis in both adult and 3-week-old genetic absence epilepsy rats from Strasbourg (GAERS) to determine if newly formed neurons within the dentate gyrus (DG) form synaptic contacts with GABAergic (gamma aminobutyric acid) and glutamatergic nerve terminals and compared to the control (non-GAERS) Wistar rats.