Acute Promyelocytic Leukemia Treated With Idarubicin Complicated by Focal Segmental Glomerulosclerosis

Bariş S., Özdil M., Topal N., Doğru Ö., Özdemir N., Sever L., ...Daha Fazla

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, cilt.32, sa.2, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 2
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1097/mph.0b013e3181b8473a
  • Dergi Adı: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: acute promyelocytic leukemia, nephrotic syndrome, focal segmental glomerulosclerosis, ischemic stroke, childhood, TRANS-RETINOIC ACID, ACUTE MYELOID-LEUKEMIA, NEPHROTIC SYNDROME, LYMPHOCYTIC-LEUKEMIA, THROMBOSIS, DAUNOMYCIN, PATIENT
  • Marmara Üniversitesi Adresli: Evet

Özet

The authors report a 9-year-old boy presenting with a left cerebral ischemic infarction as the first manifestation of acute promyelocytic leukemia. During consolidation chemotherapy, the patient developed nephrotic syndrome and a renal biopsy revealed focal segmental glomerulosclerosis (FSGS). Remission in bone marrow was achieved with chemotherapy, however, new intracranial ischemic areas developed on follow-up. Acute promyelocytic leukemia complicated by FSGS has not been previously reported in children. There may be a relationship between anthracycline treatment and FSGS. Thrombosis could be related with both leukemia and nephrotic syndrome, here thrombosis was the initial symptom, before FSGS was diagnosed.