Effects of ACE inhibition and AT(1)-receptor antagonism on endothelial function and insulin sensitivity in essential hypertensive patients

Yavuz D., Koc M., Toprak A., Akpinar I., Velioglu A., Deyneli O., ...Daha Fazla

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, cilt.4, sa.3, ss.197-203, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 3
  • Basım Tarihi: 2003
  • Doi Numarası: 10.3317/jraas.2003.032
  • Dergi Adı: JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.197-203
  • Anahtar Kelimeler: hypertension, angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, insulin resistance, vascular endothelium, oxidative stress, CONVERTING ENZYME-INHIBITORS, GLUCOSE-METABOLISM, NITRIC-OXIDE, ANGIOTENSIN, DYSFUNCTION, RESISTANCE, KININS, TOLERANCE, LOSARTAN
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective Disturbed endothelial function is closely associated with hyperinsulinaemia and insulin resistance in essential hypertension. The alms of this study were: 1) to evaluate whether the two alternative drugs, angiotensin-converting enzyme (ACE) inhibitors and Angiotensin 11 (Ang 11) antagonists, had comparable effects on glucose metabolism and endothelial function. 2) to determine whether they improve endothelial dysfunction through modulating insulin resistance and oxidative stress.