Effects of ACE inhibition and AT1-receptor antagonism on endothelial function and insulin sensitivity in essential hypertensive patients.

Yavuz D. , Koc M., Toprak A., Akpinar I., Velioglu A., Deyneli O., ...Daha Fazla

Journal of the renin-angiotensin-aldosterone system : JRAAS, cilt.4, ss.197-203, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 4 Konu: 3
  • Basım Tarihi: 2003
  • Doi Numarası: 10.3317/jraas.2003.032
  • Dergi Adı: Journal of the renin-angiotensin-aldosterone system : JRAAS
  • Sayfa Sayıları: ss.197-203


Objective Disturbed endothelial function is closely associated with hyperinsulinaemia and insulin resistance in essential hypertension. The alms of this study were: 1) to evaluate whether the two alternative drugs, angiotensin-converting enzyme (ACE) inhibitors and Angiotensin 11 (Ang 11) antagonists, had comparable effects on glucose metabolism and endothelial function. 2) to determine whether they improve endothelial dysfunction through modulating insulin resistance and oxidative stress.