Decreased Prolidase Activity in Patients with Posttraumatic Stress Disorder

Demir S., BULUT M., ATLİ A., KAPLAN İ., KAYA M. C., Bez Y., ...Daha Fazla

PSYCHIATRY INVESTIGATION, cilt.13, sa.4, ss.420-426, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.4306/pi.2016.13.4.420
  • Dergi Adı: PSYCHIATRY INVESTIGATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Sayfa Sayıları: ss.420-426
  • Anahtar Kelimeler: PTSD, Prolidase activity, Neuroprotective, NOS INHIBITOR 1-(2-TRIFLUOROMETHYLPHENYL)-IMIDAZOLE, FORCED SWIMMING TEST, NITRIC-OXIDE, OXIDATIVE-STRESS, EARTHQUAKE SURVIVORS, EXTRACELLULAR-MATRIX, ANTIDEPRESSANT-LIKE, NATURAL DISASTER, NMDA RECEPTOR, MENTAL-HEALTH
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective Many neurochemical systems have been implicated in the development of Posttraumatic Stress Disorder (PTSD). The prolidase enzyme is a cytosolic exopeptidase that detaches proline or hydroxyproline from the carboxyl terminal position of dipeptides. Prolidase has important biological effects, and to date, its role in the etiology of PTSD has not been studied. In the present study, we aimed to evaluate prolidase activity in patients with PTSD.