Antiglutamatergic therapy in Alzheimer's disease - effects of lamotrigine - Short communication


Tekin S., Aykut-Bingol C., Tanridag T. , Aktan S.

JOURNAL OF NEURAL TRANSMISSION, vol.105, pp.295-303, 1998 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 105
  • Publication Date: 1998
  • Doi Number: 10.1007/s007020050059
  • Title of Journal : JOURNAL OF NEURAL TRANSMISSION
  • Page Numbers: pp.295-303
  • Keywords: lamotrigine, glutamate, glutamate release, excitatory neurotransmitter, Alzheimer's disease, neuroprotection, therapy, GLUTAMATE, DEMENTIA, CORTEX, SCALE

Abstract

It has been proposed that excitotoxic damage by glutamatergic hyperactivity is responsible for neurodegeneration in Alzheimer's disease. Lamotrigine (LTG) inhibits presynaptic glutamate release and is considered to be effective in treatment of other neurodegenerative disorders by its cerebroprotective properties. We used LTG in 11 patients with the diagnosis of probable Alzheimer's disease. 300 mg/day administration of LTG improved word recognition, naming and depressed mood on Alzheimer Disease Assessment Scale (ADAS).