A review on the mechanistic details of OXA enzymes of ESKAPE pathogens

Avci F. G., Tastekil I., Jaisi A., ÖZBEK SARICA P., SARIYAR AKBULUT B.

PATHOGENS AND GLOBAL HEALTH, cilt.117, sa.3, ss.219-234, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 117 Sayı: 3
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1080/20477724.2022.2088496
  • Dergi Adı: PATHOGENS AND GLOBAL HEALTH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.219-234
  • Anahtar Kelimeler: B-lactamase, OXA-10, OXA-23, OXA-48, ESKAPE bugs, D BETA-LACTAMASES, EXTENDED-SPECTRUM VARIANT, CLASS D CARBAPENEMASES, ACINETOBACTER-BAUMANNII, KLEBSIELLA-PNEUMONIAE, CLASS-A, CRYSTAL-STRUCTURE, STRUCTURAL BASIS, IMIPENEM-RESISTANCE, ESCHERICHIA-COLI
  • Marmara Üniversitesi Adresli: Evet

Özet

The production of beta-lactamases is a prevalent mechanism that poses serious pressure on the control of bacterial resistance. Furthermore, the unavoidable and alarming increase in the transmission of bacteria producing extended-spectrum beta-lactamases complicates treatment alternatives with existing drugs and/or approaches. Class D beta-lactamases, designated as OXA enzymes, are characterized by their activity specifically towards oxacillins. They are widely distributed among the ESKAPE bugs that are associated with antibiotic resistance and life-threatening hospital infections. The inadequacy of current beta-lactamase inhibitors for conventional treatments of 'OXA' mediated infections confirms the necessity of new approaches. Here, the focus is on the mechanistic details of OXA-10, OXA-23, and OXA-48, commonly found in highly virulent and antibiotic-resistant pathogens Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Enterobacter spp. to describe their similarities and differences. Furthermore, this review contains a specific emphasis on structural and computational perspectives, which will be valuable to guide efforts in the design/discovery of a common single-molecule drug against ESKAPE pathogens.