A review on the mechanistic details of OXA enzymes of ESKAPE pathogens
PATHOGENS AND GLOBAL HEALTH, cilt.117, sa.3, ss.219-234, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 117 Sayı: 3
- Basım Tarihi: 2023
- Doi Numarası: 10.1080/20477724.2022.2088496
- Dergi Adı: PATHOGENS AND GLOBAL HEALTH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.219-234
- Anahtar Kelimeler: B-lactamase, OXA-10, OXA-23, OXA-48, ESKAPE bugs, D BETA-LACTAMASES, EXTENDED-SPECTRUM VARIANT, CLASS D CARBAPENEMASES, ACINETOBACTER-BAUMANNII, KLEBSIELLA-PNEUMONIAE, CLASS-A, CRYSTAL-STRUCTURE, STRUCTURAL BASIS, IMIPENEM-RESISTANCE, ESCHERICHIA-COLI
- Marmara Üniversitesi Adresli: Evet
Özet
The production of beta-lactamases is a prevalent mechanism that poses serious pressure on the control of bacterial resistance. Furthermore, the unavoidable and alarming increase in the transmission of bacteria producing extended-spectrum beta-lactamases complicates treatment alternatives with existing drugs and/or approaches. Class D beta-lactamases, designated as OXA enzymes, are characterized by their activity specifically towards oxacillins. They are widely distributed among the ESKAPE bugs that are associated with antibiotic resistance and life-threatening hospital infections. The inadequacy of current beta-lactamase inhibitors for conventional treatments of 'OXA' mediated infections confirms the necessity of new approaches. Here, the focus is on the mechanistic details of OXA-10, OXA-23, and OXA-48, commonly found in highly virulent and antibiotic-resistant pathogens Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Enterobacter spp. to describe their similarities and differences. Furthermore, this review contains a specific emphasis on structural and computational perspectives, which will be valuable to guide efforts in the design/discovery of a common single-molecule drug against ESKAPE pathogens.